William J. Brittain, PhD, Texas State University
· study the SP-MC mechanism using advanced analytical techniques to better interpret kinetics
· synthesize and characterize SP-inspired molecular systems that overcome limitations
·
The photoinduced and thermal isomerization of SP have been extensively studied. The first step in the photochemical process is Cspiro-O bond cleavage to generate an excited triplet or singlet state that decays within picoseconds and produces a mixture of geometric isomers of MC that differ in cis/trans (C or T) conformations about the a, b and g bonds linking the indole and chromene subunits (Scheme 2). For 1',3',3'-trimethyl-6-nitrospiro[chromene-2,2'-indoline] (6-nitro-BIPS, SP-1), the photochemical reaction proceeds via a triplet mechanism followed by intersystem crossing to 3CCC merocyanine and subsequent conversion to 3CTC and 3TTC. Theoretical investigations suggest 3CCC* decays in picoseconds while the lifetime of the 3CTC and 3TTC species is milliseconds. Evidence for the CTC form of 6-nitro-BIPS comes from laser-desorption/electron diffraction and excited state dynamics.
Here we used electrospray ionization (ESI) ion mobility-mass spectrometry (IM-MS) to examine both equilibrated and irradiated samples of spiropyrans 1-3 in methanol (Scheme 2) to gain further experimental insight into the photoisomerization. IM-MS provides information on the molecules' shapes and sizes based on collision cross-section (CCS), in addition to mass and compositional information. Our interpretation of the IM-MS experimental data argues for presence of a long-lived (>milliseconds) CCX (refers to two of the four MC isomers with cis configuration at the central bond) isomer of MC. The lifetime of this proposed species is considerably longer than the sub-nanosecond lifetimes reported previously.
Scheme 2. General Structures of SPs 1-3 and their corresponding MCs.
Based on our results, we conclude that the likely reaction pathway is: SP ⇋ CCT/CCC ⇋ TTC/CTC. Theoretical values for the relative energies of the TTC and TTT isomers revealed a minor difference for calculations in vacuo versus DCM solution. We feel our results are reflective of SP-MC dynamics and the contribution of field effects does not alter our conclusions significantly. Mechanistic elucidation of the elementary steps in SP-MC isomerization has been largely limited to transient spectroscopy and model systems. The combination of ESI with IM-MS provides additional information on the structure-dynamics of this important photochromic system.
This study has been recently published in Chemical Communications.[3]
References
1. “Reactivity of tetrahydrochromeno[2,3-b]indoles: chromic indicators of cyanide,” Douglas, N.; Neef, C. J.; Rogers, R. A.; Stanley, J. A.; Armitage, J.; Martin, B.; Hudnall, T. W.; Brittain, W. J. J. Phys. Org. Chem. 2013, 688-695.
2. “Transient absorption studies of tetrahydrochromeno[2,3-b]indole ring-opening,” Perry, J. W.; Brittain, W. J. J. Phys. Org. Chem. to be submitted.
3. A study of the spiropyran-merocyanine system using ion
mobility-mass spectrometry: experimental support for the cisoid conformation,”
Rogers, R. A.; Rodier, A. R.; Stanley, J. A.; Douglas, N. A.; Li, X.; Brittain,
W. J. Chem. Commun. DOI: 10.1039/c3cc47697a.
Copyright © 2014 American Chemical Society