AmericanChemicalSociety.com

During the proposed time period, PI's group discovered the novel Lewis-base catalyzed nitroalkene activation and applied this new reaction mode into the preparation of complex organic molecules that extended the value the petroleum products. These transformations include the one-step synthesis of piperidine, isoxazoline-N-oxide, dihydrofuran. These transformations gave the complex products in good yields and excellent stereoselectivity. Extension of this strategy allowed the formation of 4,5-disubsitututed 1,2,3-NH-triazoles, which later were applied into the coordination with transition metal. Unique reactivity was obtained for the triazole bound Rh, Ir, B and Au complexes that allowed the discovery of new methods to further extend the complexity of organic compounds and extend the value of petroleum products.