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44139-GB3
Doubly Bridged Metallocenes with Two Distinct Interannular Linkers: Synthesis and Regioselectivity for alpha-Olefin Polymerization

Deanna L. Zubris, Villanova University

During the past year, my research group has pursued the synthesis of two sterically hindered ligands and their corresponding metal complexes.  These targets are: (1) singly bridged zirconocenes with one bulky phenyl-phosphine interannular linker (described in year 1 report), and (2) a novel pyridine bis(imine) ligand with t-butyl substitution on both imino carbon atoms, and attempted metallation with iron(II)chloride (mentioned with minimal detail in year 1 report).  With the success of these projects during the year 2 grant period, the preparation of doubly bridged zirconocenes with two distinct interannular linkers was pursued less intensely to allow the former two projects to develop to the stage necessary for publication.  However, the singly linked ligand for project 1 is a synthetic precursor to a doubly bridged zirconocene with two distinct interannular linkers, and therefore project 1 provides some valuable insight for our long term synthetic goals.

During year 2, the chemistry for project 1 was developed sufficiently for publication.  The synthesis of neutral ligand, 3, and dipotassio salt, 4, was carried out reproducibly and both were characterized by 1H, 13C{1H}, and 31P{1H} NMR spectroscopy.  Syntheses of rac/meso-{PhP(3-t-Bu-C5H3)2}Zr{Me3SiN(CH2)3NSiMe3} (rac-5/meso-5, in a 2 to 1 ratio) and rac/meso-{PhP(3-t-Bu-C5H3)2}Zr{PhN(CH2)3NPh} (rac-6/meso-6, in a 1 to 3 ratio) was achieved by metallation of 4 with Zr{RN(CH2)3NR}Cl2(THF)2 (where R = SiMe3 or Ph, respectively), using the chelate-controlled metallation method described previously by Professor Richard F. Jordan (University of Chicago).  Again, multinuclear NMR spectroscopy was used for characterization; both rac-5 and rac-6 were further analyzed crystallographically.  During the course of these studies, we discovered that isolated samples of rac-5/meso-5 (with a 2 to 1 ratio, in tetrahydrofuran-d8 solvent) slowly isomerized to enhance the relative amount of rac isomer in solution.  Similar behavior was observed for isolated samples of rac-6/meso-6 (with a 1 to 3 ratio, in tetrahydrofuran-d8 solvent); the proportion of the rac isomer increased over time.  We monitored the kinetics of these isomerizations using 31P{1H} NMR spectroscopy, and found that the isomerization rate for 5 is more than 15 fold greater than that for 6.  In separate experiments, we found that these rac/meso equilibrium ratios are reached at a faster rate when isolated samples of 5 and 6 are exposed to tetrabutylammonium chloride in tetrahydrofuran-d8 solvent.  Addition of neutral ligand, 3, to isolated samples of 5 and 6 in tetrahydrofuran-d8 solvent also accelerates isomerization, but not as dramatically as tetrabutylammonium chloride.  We invoke nucleophile (either chloride or the phosphine interannular linker) promoted dissociation of one cyclopentadienyl ring as the critical mechanistic step in our observed rac/meso isomerizations.  In future work, we will capitalize on our ability to affect the controlled isomerization of rac-5/meso-5 and rac-6/meso-6 and will use pure rac samples for conversion to the zirconocene dichloride olefin polymerization precatalyst, rac-{PhP(3-t-Bu-C5H3)2}ZrCl2

 

During year 2, the chemistry for project 2 was advanced to allow for submission of a manuscript that is currently under review.  We developed a stepwise synthetic method for assembly of a bis(imino)pyridine ligand with t-butyl substituents on the imino carbon atoms, 2,6-{(2,4-Me2-C6H3)NC(t-Bu)}2C5H3N (10).  The use of an imidoyl chloride (8) as an electrophile in combination with in situ generated 2-bromo-6-lithiopyridine has not been reported prior to this work.  We were able to characterize mono(imino)pyridine, 9, and bis(imino)pyridine 10, via single crystal X-ray diffraction.  Compound 10 adopts an interesting “closed” geometry, which is quite different from the more “open” geometry reported in the literature for 2,6-{(2,4-Me2-C6H3)NC(Me)}2C5H3N, the analogous ligand with methyl substituents on the imino carbon atoms.  We hypothesize that the thermodynamic preference for the “closed” geometry of our ligand (both in the solid state and also borne out by gas-phase calculations) hinders metallation using iron(II)chloride.  Indeed, metallation attempts of 10 under forcing conditions (such as use of refluxing 1-hexanol over the course of days) does not yield the desired iron(II)chloride complex, 11.  In future work, we plan to use our new stepwise synthetic method to prepare C1-symmetric ligands with differing substitution on the imino carbon atoms; metallation will be attempted using iron(II)chloride as well as other iron(II) sources, such as FeCl2(THF)1.5

 

The zirconium chemistry described above (project 1) has been accepted as a full paper in press for the Journal of Organometallic Chemistry.  Notably, Jonathan Axtell is the first author for this publication; he is currently a junior undergraduate student and was supported for years 1 and 2 of this grant.  We have another full paper under review for Dalton Transactions; this paper recounts the bis imino(pyridine) chemistry described above (project 2).  This submission also has an undergraduate first author, Janelle Steves; she is a current junior and was supported for years 1 and 2 of the grant.  In order to further disseminate the work carried out during the grant period, we intend to submit abstracts for two presentations at the ACS National Meeting in Spring 2009. 

 

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