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46587-G3
Transition-Metal-Mediated Activation of Sulfur Toward C–S Bond Formation
Jan-Uwe Rohde, University of Iowa
Synthesis, Characterization, and Reactivity of Iridium(I)
Complexes Supported by Guanidinato Ligands
Monoanionic
nitrogen-donor ligands represent an important class of supporting ligands and
have been widely used in the coordination chemistry of transition metals to
impart diverse properties and reactivity. Prominent examples include
poly(1-pyrazolyl)borate, β-diiminate, aminotroponiminate, and
amidinate scaffolds. Since guanidinates are conceptually related to the latter
three systems, they may be expected to be similarly well-suited as supports for
reactive metal centers. Although complexes of guanidinates are known for many
metals and metalloids from across the periodic table, examples involving
electron-rich transition metal centers in low oxidation states are limited to
only a few di and tetranuclear complexes, which mainly involve coinage metals.
We have synthesized
IrI(cod) complexes of a series of bidentate N,N-dialkyl-N',N''-diarylguanidinate
anions, ArNC(NR2)NAr–, to explore the coordination
ability of this ligand platform to transition metals in low oxidation states
and to probe its utility in tuning the reactivity of the coordinated metal
center. The neutral guanidines, ArN=C(NR2)NHAr, were readily
prepared from the corresponding thioureas, ArHNC(S)NHAr, and the appropriate
amines, HNR2, according to literature methods for related compounds.
As shown in Scheme 1, treatment with MeLi and subsequent transmetallation using
[{Ir(cod)}2(μ-Cl)2] under an inert atmosphere
furnished the yellow IrI complexes of the anionic guanidinates, [Ir{ArNC(NR2)NAr}(cod)], in good yields.
Scheme 1. Synthesis of [Ir{ArNC(NR2)NAr}(cod)] Complexes
The ligands and
complexes were fully characterized by elemental analysis, mass spectrometry,
electronic absorption, 1H and 13C NMR spectroscopy, and
X-ray crystallography (Figure 1). Detailed inspection of the structural and 13C
NMR data of these complexes revealed that the anionic dialkyldiarylguanidinates
can still function as strongly donating ligands when bound to the IrI(cod)
unit. For example, the structural data indicate significant NR2
lone-pair donation, and the d(13CC=C)
resonance signals, which reflect increased Ir-to-cod π
back-bonding, suggest that the dialkyldiarylguanidinates may be considered
stronger donors than κ2-binding tris(pyrazolyl)borates
and β-diketiminates but weaker donors than tris(pyrazolyl)borate-κ3
and cyclopentadienyl ligands.
Figure 1. Molecular structures of [Ir{PhNC(NEt2)NPh}(cod)]
(left) and [Ir{(2,6-Me2C6H3)NC(NMe2)N(2,6-Me2C6H3)}(cod)]
(right); hydrogen atoms have been omitted for clarity; color
key: pink = Ir, blue = N, gray = C.
In solution, the
[Ir{ArNC(NR2)NAr}(cod)] complexes readily react with dioxygen at
ambient temperature and pressure (Figure 2). Mono and di-oxygenated products
were identified from the reaction mixtures. A systematic investigation of
substituent effects showed that the reaction rates can be altered by the
electronic and steric properties of substituents in both amino and amidinato
positions of the guanidinato ligand. The new complexes also react with
elemental sulfur, and the elucidation of reaction mechanisms and products is
currently underway.
Figure 2. Reaction of [Ir{PhNC(NMe2)NPh}(cod)] in toluene
with O2 at 0 °C as monitored by electronic
absorption spectroscopy. Inset: Time courses of the reactions of [Ir{ArNC(NR2)NAr}(cod)] complexes with O2.
In summary, we
have prepared and characterized mononuclear complexes of a low-valent d-block
metal center coordinated by didentate guanidinato(1–) ligands and thus expanded
the scope of this ligand platform in transition-metal chemistry. Spectroscopic
evidence suggests that the N,N-dialkyl-N',N''-diarylguanidinates
employed here function as stronger donors than other monoanionic,
nitrogen-based scaffolds, such as tris(pyrazolyl)borates-κ2
and β-diketiminates, when bound to the IrI(cod) unit.
The trends observed in the reactions of these complexes with O2
illustrate the potential that the guanidinato(1–) platform has to offer for
facile modulation of the reactivity of transition metal complexes.
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