Synthesis of Physostigmine


Percy L. Julian and Chemistry at Depauw University
DePauw graduate Percy Julian, 1920The early 1930s was a time of great chemical research productivity at DePauw. It was in this decade that William M. Blanchard, Dean of the University, hired Percy Julian as a research fellow. Blanchard, who also served as head of the chemistry department, had been Julian's mentor during his undergraduate years at DePauw. Julian had received a Ph.D. degree in Vienna in 1931 and was in need of a position in which he could continue his research career. The DePauw chemistry program he joined in 1933 had roots that extended back to 1839 when the university was Asbury College and chemistry was offered as a natural science course taught by the president, Matthew Simpson. Chemistry became a distinct department in 1881 under the direction of Phillip S. Baker. The department prospered and a chemistry major was established in 1896. Percy Julian graduated from this program in 1920.

DePauw University Science Club, ca 1920As a research fellow from 1932 to 1935, Julian, working with his colleague from Vienna, Josef Pikl, and several DePauw students, produced a phenomenal number of high-quality research papers. One such paper appeared in the April 1935 issue of the Journal of the American Chemical Society. This paper, entitled "Studies in the Indole Series V. The Complete Synthesis of Physostigmine (Eserine)," which explained how Julian synthesized physostigmine, is undoubtedly the most significant chemical research publication to come from DePauw. The student and faculty collaborative approach, promoted by Julian, has continued to the present, and today most of the research at DePauw is done in collaboration with students.

After the grant funding Julian's position expired, Blanchard wanted to appoint Julian to the teaching staff. Despite Julian's achievements, the Board of Trustees did not allow it. Julian left DePauw to pursue a distinguished career in industry.

In 1967, Julian was appointed to the DePauw University Board of Trustees. Also that year, planning began for a new science building, which would replace the 65-year-old Minshall Laboratory, and construction commenced in 1968. The Science and Mathematics Center was dedicated in September 1972, with Percy Julian giving the dedication address, "Science and the Good Life of Man." Following Julian's death, DePauw University named the Percy L. Julian Science and Mathematics Center in his honor.

 

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