Harold Ray Snyder and Antimalarials
(1910-1994)

C  O  N  T  E  N  T  S

Noyes Laboratory:
One Hundred Years of Chemistry


A Century of Accomplishment
The Bare Facts
Nobel Prize Winners
ACS Presidents
Priestley Medal Winner


Fine Chemicals

The Illinois State Water Survey

Chemists and Chemistry at Noyes:
Roger Adams:
"The Chief"
Ludwig F. Audrieth and Synthetic Sweeteners
John C. Bailar Jr. and Coordination Chemistry
St. Elmo Brady: Pioneer
George L. Clark and High-Intensity X-Ray Tubes
Willis H. Flygare and Microwave Spectrometry
Reynold C. Fuson: Teaching Chemistry
Herbert S. Gutowsky and NMR Spectroscopy
B. Smith Hopkins and the Chemistry of Rare Earths
Henry Fraser Johnstone and the Study of Air Pollution
Herbert A. Laitinen and Analytical Chemistry
Carl "Speed" Marvel: Advances in Polymer Chemistry
William A. Noyes: The Department Comes of Age
Arthur W. Palmer: The Early Years
Samuel W. Parr and Applied Chemistry
Charles C. Price III and Antimalarials
Worth H. Rodebush and Physical Chemistry
William C. Rose and Amino Acids
George F. Smith and the Aerosol Can
Harold R. Snyder and Antimalarials
Marion Sparks and Chemical Information

Landmark Designation

Harold Snyder took a B.S. in chemistry at the University of Illinois and a Ph.D. at Cornell in 1935 with J. R. Johnson. After spending a year with the Solvay Process Company, Snyder joined the faculty of the Chemistry Department at Illinois, becoming a full professor in 1945.

From 1957 to 1960 Snyder served as Associate Head of the Chemistry Department and from 1960 until his retirement in 1976 he had the additional responsibility of Associate Dean of the Graduate School and Secretary of the Research Board. During the Second World War, Snyder carried on work for the National Defense Research Committee, the Committee on Medical Research, and the W. P. B. Rubber Research Program. In the battle against malaria, he and his students worked along with Charles Price and Nelson Leonard to produce a crucial intermediate path to chloroquine. Their efforts led to the production of sufficient quantities of chloroquine for use in the Pacific Theater to fight malaria-carrying mosquitoes.

Snyder was a classical organic chemist who investigated the synthesis of amino acids, heteroaromatic systems, and the reactions of amines and indoles. He invented a new reaction process with C-alkylation of quaternary ammonium salts. Snyder investigated mechanisms of organic reactions, especially polymerization, Diels Alder reactions, and Mannich reactions.

 


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