Charles Coale Price III and Antimalarials
(1913-2001)

C  O  N  T  E  N  T  S

Noyes Laboratory:
One Hundred Years of Chemistry


A Century of Accomplishment
The Bare Facts
Nobel Prize Winners
ACS Presidents
Priestley Medal Winner


Fine Chemicals

The Illinois State Water Survey

Chemists and Chemistry at Noyes:
Roger Adams:
"The Chief"
Ludwig F. Audrieth and Synthetic Sweeteners
John C. Bailar Jr. and Coordination Chemistry
St. Elmo Brady: Pioneer
George L. Clark and High-Intensity X-Ray Tubes
Willis H. Flygare and Microwave Spectrometry
Reynold C. Fuson: Teaching Chemistry
Herbert S. Gutowsky and NMR Spectroscopy
B. Smith Hopkins and the Chemistry of Rare Earths
Henry Fraser Johnstone and the Study of Air Pollution
Herbert A. Laitinen and Analytical Chemistry
Carl "Speed" Marvel: Advances in Polymer Chemistry
William A. Noyes: The Department Comes of Age
Arthur W. Palmer: The Early Years
Samuel W. Parr and Applied Chemistry
Charles C. Price III and Antimalarials
Worth H. Rodebush and Physical Chemistry
William C. Rose and Amino Acids
George F. Smith and the Aerosol Can
Harold R. Snyder and Antimalarials
Marion Sparks and Chemical Information

Landmark Designation

Charles Price joined the faculty of the University of Illinois in 1936, the same year he received his Ph.D. from Harvard University, where he studied under L. F. Fieser. He left ten years later to become head of the department of chemistry at Notre Dame. Price’s research interest centered on the mechanisms of various organic reactions, such as substitutions in aromatic compounds; addition, elimination, and replacement reactions; vinyl-type addition polymerization and copolymerization; the hydrolysis and oxidation of chemical warfare agents; and the reaction of biopolymers with alkylating agents. Price specialized in polymers, rubbers, and resins. He held important patents on synthetic rubber, which were marketed commercially by Rohm and Haas.

Price played a crucial role in the battle against malaria during the Second World War. Price and his student, Royston Roberts, invented an optimum synthesis of a crucial intermediate on the path to chloroquine while working on the Antimalarial Research Program, which was funded by the National Defense Research Council. In developing the method, Nelson Leonard joined the effort of the students of Price and Harold Snyder to produce the intermediate on a grand scale. The pilot plant at Illinois produced sufficient chloroquine in time for its use in the Pacific Theater against malaria-carrying mosquitoes. During the war years Price also directed projects for the Chemical Warfare Service and the Committee on Medical Research.

Price served as President of the American Chemical Society in 1965 and won the ACS Award in Pure Chemistry in 1946 and the ACS Award for Creative Invention in 1974. Price played a significant role in the establishment and growth of the Chemical Heritage Foundation. As founding chair of the Foundation, he helped it gain recognition and support from other chemical organizations and assisted in locating a permanent home for the CHF in Philadelphia’s historic district.

 


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